جامعة بلاد الرافدين - Bilad Alrafidain University - Sadiq Jaafer

م.م صادق جعفر رشيد

Sadiq Jaafer

تدريسي : كلية الصيدلة

Teaching : University Of Pharmacy

ماجستير علوم صيدلانية

Master degree in computer pharmaceuticals science- medicinal chemistry

Sadiq@bauc14.edu.iq

Sadekjafar82@gmail.com

News

Research

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Syllabuses

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Articles in the magazine

Syllabuses

Syllabuses - 2

Dep.	Step.	Sem.	code	No.	Des.	Syllabuses
University Of Pharmacy	three	term 1	BHB31IOPHCHE	3		Inorganic pharmaceutical Chemistry
University Of Pharmacy	three	term 2	BHB32OR.PHARM.CHEM.I	4		Organic Pharmaceutical Chemistry I

Research

	2024	IAR Journal of Pharmacy
"Abstract: Adjective: The purpose of this study was to evaluate the inhibitory effect of the extract derived from Cnicus Benedictus blossom on the growth of cervical cancer cells in a laboratory environment. Furthermore, the study intended to explore any possible synergistic impact when mixing the extract with vinblastine. Method: Hela cancer cell line was utilized to determine the cytotoxicity of Cnicus Benedictus L. floral extract, vinblastine and the mixture between them; the concentration involved was raged between (1-10000) μg/ml, for each one, at 24 and 72 incubation periods. Quantitating drug interaction between mixture components was evaluated by utilizing a compusyn computer program for calculation Combination index (CI) and Dose reduction index. Results: The study showcased the efficacy of plant extract in lessening the growth of cervical cancer cells. The inhibition of growth was seen to be dependent on the concentration and time for both the plant extract and the mixture of plant extract and vinblastine. On the other hand, the cytotoxicity behavior of vinblastine was primarily dependent on time. The result of quantitating drug interaction between mixture components showed diverse behavior, at lower concentration exhibiting synergism, mainly at 24 hrs. incubation period. In contrast, moderate and higher concentrations exhibited antagonism. At the same time, the result of the dose reduction index at 24 hrs. of incubation exhibited a favorable reduction in the concentration of vinblastine in the mixture compared with plant extract. In contrast, at 72 hrs. of incubation, all vinblastine and the majority of plant extract concentrations showed an unfavorable reduction. Conclusion: The study showed that the alcoholic extract of Cnicus Benedictus considerably declined the proliferation of cervical cancer cells corresponding to the inhibitory effect of vinblastine. The result also demonstrates that the mixture of vinblastine and plant extract lessens cervical cancer cell proliferation via cycle-specific and non-cycle-specific cytotoxicity. In contrast, vinblastine predominantly has cycle-specific cytotoxicity. Vinblastine and Cnicus Benedictus L. flower extract have two cytotoxic patterns, synergism at lower combination concentrations and antagonism at intermediate and higher doses."

	2024	Scientific Research Journal of Pharmacy
"Abstract: Fifty male rats allocated as five groups were adopted, to elucidate the effect of resveratrol against the statins; lovastatin and rosuvastatin. The results disclosed that cholesterol did cause significant elevations in erythrocyte count, hemoglobin, hematocrit, leukocytes and platelets counts with significant declinations in lymphocytes and monocytes. Rosuvastatin caused significant decrease in hemoglobin, hematocrit and leukocytes and the Lovastatin caused significant declination in the leukocytes only. Resveratrol caused all the parameters to be without significant differences comparing with control group. Further details are disclosed in the results."

	2023	Qeios
"Abstract Background: Protein and peptide drugs offer significant promise as therapeutic agents due to their superior efficacy and reduced toxicity compared to conventional chemical drugs. Nevertheless, difficulties with medication delivery techniques impede their practical deployment. Poor absorption limits non-invasive delivery methods such as nasal, pulmonary, and transdermal distribution, whereas oral administration suffers from low bioavailability and stability problems. Parenteral administration involves certain difficulties, such as low patient compliance and pain, but it also shows promise as a protein-based drug delivery method. Aim: This review article aims to explore the development of structure-based nanocarriers designed for drug delivery, which have shown potential to address the limitations associated with protein and peptide drug delivery. Materials and Methods: A complete literature review was undertaken utilizing Google Scholar and other trustworthy scientific sources to acquire relevant material for this study. Keywords included in the search were “Nanocarriers”, “bioavailability”, “absorption”, “peptide”, “protein drug delivery”, and “permeability”. This review investigated peerreviewed publications, research papers, and reviews relating to the issue of inclusion. Results: The review highlights the advancements in structure-based nanocarriers for protein and peptide drug delivery. These nanocarriers have demonstrated reduced side effects and improved therapeutic efficacy compared to free drug molecules. The ability of new and advanced nanocarriers to facilitate targeted drug delivery, overcome physiological barriers, and enable controlled drug release within the body is discussed. Conclusion: By developing structure-based nanocarriers, the problems with conventional drug delivery techniques may be addressed, and protein and peptide medication delivery can be improved. Potential benefits of these nanocarriers include enhanced absorption, tailored drug administration, and greater bioavailability, which might result in safer and more successful treatment results for a range of illnesses"

	2024	Web of Scientists and Scholars: Journal of Multidisciplinary Research
Abstract Background: Many of non-antibiotics drug such as anesthetics, diuretics, anticoagulants, antihypertensive and mucolytic drugs, have shown some antimicrobial activity. Antimicrobial resistance is a global human and economic burden that is increasing annually. No new antimicrobial is effective against microbial resistance however there is increase the development of bacterial drug resistant. For that its important to find a drug to limit or overcome the bacterial resistant. Our object to find out the effect of Macitentan against different microbial target associated with drug resistant Method: The molecular docking of Macitentan as possible antibacterial drug against NMD 1, Als3 FmlD, Com E, and HSK shows height affinity. The binding energy was 7.28, 5.52, 4.38, 6.60, and 5.64 respectively. Result: the drug shows good binding activity against NDM-1 binding energy (-7.28 kcal/mol), Com E (-6.60 kcal/mol) , moderate activity for Als3 (-5.52 kcal/mol) , FmlD (-4.38 kcal/mol) and HSK (-5.64 kcal/mol) Conclusion Macitentan may be a useful resource for the creation of novel anti-infective substances. Docking experiments were conducted on two significant targets, purpose elucidating a putative mechanism of action for the molecule that was shown to be the most active.

	2022	ACE Research Journal of Microbiology and Biotechnology
"Abstract: Streptococcus pyogenes emm typing has become one of the best access used in molecular typing of group A streptococci (GAS). Accurate identification of GAS is an essential part of epidemiological and pathogenetic studies of streptococcal diseases, assist knowledge of the dynamics of emm types in a region thus may threw light on the pathogenesis of GAS infections. Streptococcus pyogenes has been diagnosed according to their morphological and biochemical characteristics, as well confirmed by using Vitek‐2 system and molecular identification according to the results of amplification and sequencing of 16S rRNA gene. On the other hand, emm typing was done according to the guidelines stated by the centers for disease control and prevention (CDC) protocol guidelines. A total of 93 bacterial isolates were obtained from 500 clinical samples after culture on suitable media, out of these only 22 isolates were identified as S. pyogenes. Moreover, the results showed that these isolates belong to seven stereotypes (emm 104.1, emm 28, emm 44, emm 63, emm 1, emm 5.103 and emm 90) of emm types E2, E3, E4, E6 and A. C3 and M5 respectively."

	2024	International Journal of Pharmacy and Pharmaceutical Studies
Silibum Marianum, which is known as milk is widely used in traditional medicine for its therapeutic properties. It has shown that the main component of the Selipine belongs to a group of flavonoids called Flavonoliganz, known as its antioxidant and anti-inflammatory impacts, and the cellippine has been characterized by its unique buildings Accordingly, Silibum Marianum shows promising potential in enhancing cardiovascular health by making cholesterol levels, hazarding the composition of bridges, and the exercise of antioxidant and anti-inflammatory procedures These characteristics and their features are antioxidants, they do so play a crucial role in protecting cells from damage caused by oxidative and discrepancies in chronic diseases such as cancer, diabetes and nervous degeneration disorders and research suggested In addition, investigations explored its potential anti-cancer properties, including inhibition of cancer cell proliferation, incitement of the death of programmed cells, and mitigate side effects of chemotherapy. In essence, Silibum Marianum, is introduced by Silippians as the active biological component, a range of potential health benefits ranging from liver support to cardiovascular protection and antioxidants effects.

	2023	Pakistan
"Cancer one of the most serious health problems today and breast cancer most common cancer occur in woman’s use chemotherapy has disadvantage such as resistance and non‐selectivity toward cancer cells,2‐mercaptobenoxazole and its derivatives important heterocyclic compound in pharmaceutical chemistry as anticancer. The aim is synthesized various derivatives of 2‐MBO and their structures confirmed through IR, 1H‐NMR, 13C‐NMR, DSC and elemental analysis. The synthesized compounds were docking with progesterone receptors showing good binding energy affinity. All synthesized compounds were consistent with DSC, 1H‐NMR, 13C‐NMR, FT‐IR and elemental analysis and docking against progesterone receptor. Our findings indicate the potency of ZS5 as candidate for the development of anti‐breast cancer."

	2024	European Science Methodical Journal
This study is included synthesis and characterization of a number of complexes for Silver(I) ion, with molecular formula of the complexes: [{Ag(CAPR)(NO3). (H2O)} where: CAPR=Captopril. The complexe were prepared from silver nitrate with ligands 1:1 in 25 oC. The complexe were characterized by means of the the Ultraviolet visible spectrum UV, the flame atomic absorption, And the CHN analysis, This complexe were studied for their effect against some species of bacteria and fungi. The study showed that the complex {Ag(CAPR)NO3H2O} had the inhibitory ratio to bacteria and fungi.

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