جامعة بلاد الرافدين - Bilad Alrafidain University - م.م. مروان ابراهيم عبدالكريم

م.م. مروان ابراهيم عبدالكريم

Marwan I. Al-Zuhairi

تدريسي : كلية الصيدلة

Teaching : University Of Pharmacy

ماجستير/ علوم صيدلانية

M.Sc. pharmaceuticals

marwanibrahim@bauc14.edu.iq

Marwan1192@outlook.com

السيرة الذاتية

نشاطات التدريسي

البحوث المنشورة

المؤلفات

المقررات المكلف بها

المحاضرات

مشاريع التخرج

المقالات داخل المجلة

المقررات المكلف بها

المقررات المكلف بها - 2

القسم	المرحلة	الفصل	رمز المقرر	الوحدات	توصيف	المقرر
كلية الصيدلة	المرحلة الثالثة	فصل اول	BH31PHACGII	3		Pharmacognocy II
كلية الصيدلة	المرحلة الثالثة	فصل ثاني	BH31PHACGIII	3		Pharmacognocy III

البحوث

	2024	IAR Journal of Pharmacy
"Abstract: Adjective: The purpose of this study was to evaluate the inhibitory effect of the extract derived from Cnicus Benedictus blossom on the growth of cervical cancer cells in a laboratory environment. Furthermore, the study intended to explore any possible synergistic impact when mixing the extract with vinblastine. Method: Hela cancer cell line was utilized to determine the cytotoxicity of Cnicus Benedictus L. floral extract, vinblastine and the mixture between them; the concentration involved was raged between (1-10000) µg/ml, for each one, at 24 and 72 incubation periods. Quantitating drug interaction between mixture components was evaluated by utilizing a compusyn computer program for calculation Combination index (CI) and Dose reduction index. Results: The study showcased the efficacy of plant extract in lessening the growth of cervical cancer cells. The inhibition of growth was seen to be dependent on the concentration and time for both the plant extract and the mixture of plant extract and vinblastine. On the other hand, the cytotoxicity behavior of vinblastine was primarily dependent on time. The result of quantitating drug interaction between mixture components showed diverse behavior, at lower concentration exhibiting synergism, mainly at 24 hrs. incubation period. In contrast, moderate and higher concentrations exhibited antagonism. At the same time, the result of the dose reduction index at 24 hrs. of incubation exhibited a favorable reduction in the concentration of vinblastine in the mixture compared with plant extract. In contrast, at 72 hrs. of incubation, all vinblastine and the majority of plant extract concentrations showed an unfavorable reduction. Conclusion: The study showed that the alcoholic extract of Cnicus Benedictus considerably declined the proliferation of cervical cancer cells corresponding to the inhibitory effect of vinblastine. The result also demonstrates that the mixture of vinblastine and plant extract lessens cervical cancer cell proliferation via cycle-specific and non-cycle-specific cytotoxicity. In contrast, vinblastine predominantly has cycle-specific cytotoxicity. Vinblastine and Cnicus Benedictus L. flower extract have two cytotoxic patterns, synergism at lower combination concentrations and antagonism at intermediate and higher doses."

En