جامعة بلاد الرافدين - Bilad Alrafidain University

م.د.حيدر عبد الحافظ كرجي (12 بحث)

" Bioequivalence and Pharmacokinetic Evaluation of Two Batches of Cephalexin Capsules in Healthy Volunteer"
	2020	Journal of Pharmaceutical Sciences and Research
"The aim of this study is to evaluate the difference in pharmacokinetic parameters between the same brand drugs containing Cephalexin as the active ingredient distributed to both the private sector and the governmental sector in Jordan. Method: Plasma samples of two healthy volunteer groups have been examined at different time intervals after oral administration of Cephalexin 500 mg obtained from both private and governmental health sectors, and the pharmacokinetic parameters such as area under plasma concentration time curve (AUC), maximum plasma concentration (Cmax), and time to reach maximum plasma concentration (Tmax), have been measured after conducting high performance liquid chromatography (HPLC) experiment. Results: Measurements have shown a significant difference in almost all parameters between Cephalexin from the private sector and that from the governmental sector that support the call for more control and regulations on drugs supplied to governmental health sectors. Conclusion: More control on drugs supply for governmental hospitals and health centers and almost all drug companies must provide a proof for bioequivalence for their drugs going to that sector and not rely only on that bioequivalence comparison done for registration and FDA requirements"
" Efficacy of Follitropin-A (Gonal-F) versus Follitropin-B (Puregon) for controlled ovarian stimulation in women undergoing in vitro fertilization (IVF)"
	2019	International Journal of Pharmaceutical Quality Assurance
"The purpose of this study was to compare the efficacy of two recombinant follicle-stimulating hormone (FSH) on pregnancy rates in infertile patients. Material and Methods: between 2015-2017, 387 females intended to have in vitro fertilization (IVF) for infertility treatment (226 patients use Gonal-F and 161 using Puregon. Results: Serum E2 concentration at hCG time was higher with follitropin-a treated patients, and a larger number of retrieved oocyte result in a large number of the transferred embryo, and high pregnancy rate than Follitropin-b treated patients. Conclusions: Gonal-F (Follitropin-a) is associated with a potential stimulatory effect on ovaries. Puregon (Follitropin-b) was associated with a lower clinical pregnancy rate (PR). E2 level 5-7 days after stimulation can be used as an indicator of the success of IV"
Effects of sildenafil on lipid profile and glycemic control in patients with type 2 diabetes mellitus and metabolic syndrome
	2014	International Journal of Basic & Clinical Pharmacology
" Insulin resistance impairs nitric oxide (NO) bioavailability; obesity promotes a state of metabolic syndrome and damages the vascular endothelium by altering lipid profile. Phosphodiesterase-5 (PDE-5) inhibitors restore NO signaling may improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor; sildenafil will improve fasting plasma glucose (FPG), triglyceride (TG) levels and body weight, in obese diabetic patients. Methods: Totally, 25 obese diabetic male patients with metabolic syndrome treated with sildenafil 25 mg daily for 3 months. Body weight, FPG levels, and lipid profile were determined monthly. Results: Treatment with sildenafil caused a reduction in fasting glucose levels, fasting TGs, cholesterol, low-density lipoprotein (LDL), very-LDL and increased high-density lipoprotein; body weight was significantly reduced. Conclusion: We have provided the first evidence that sildenafil therapy improve glycemic control, lipid profile and body mass index in diabetic patients with metabolic syndrome"

ا. م. د. مازن رزوقي محمد (0 بحث)

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م.م.ايناس سامي غلي (0 بحث)

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م. م. فرح عبد الكريم عبد العباس (3 بحث)

Isolation and identification of terpenes in Euphorbia tirucalli cultivated in iraq
	2021	IJDDT
Phytochemical investigation of euphorbia tirucalli ,scopoletin and quercitrin isolation
	2021	IJDDT
Phytochemical investigation of Euphorbia tirucalli cultivated in iraq
	2021	Ljddt
Phytochemical investigation of euphorbia tirucalli cultivated in iraq and isolation and identification of scopoletin and quercetrin

م.م بسام عطا علي (2 بحث)

PHARMACOLOGICAL PROPERTIES OF SPIRULINA SPECIES: HEPATOPROTECTIVE, ANTIOXIDANT AND ANTICANCER EFFECTS
	2024	FARMACIA, 2023, Vol. 71, 4
"Since the older days, spirulina has been consumed as a vital food supplement derived from algae. The properties of this alga, such as anticancer, antioxidant and hepatoprotective, have great significance in enhancing the quality of life and contributing to better health. The affliction of liver diseases and cancer is widespread among humanity, causing significant health issues. Thus, the importance of the current work is evident. The purpose was to assess the pharmacological properties of spirulina species concerning their capacity to guard the liver, counteract oxidation and combat cancer. In order to find the most comprehensive information, an intensive hunt was launched on various online databases such as Google Scholar, Scopus, PubMed and Medline. The focus was only on complete experimental and clinical works that surfaced between 2000 and 2019. 2064 related articles were found, of which 58 met the requirements of the present work; they were analysed by documentary analysis and grouped into clusters according to their pharmacognosy properties. According to the articles reviewed, spirulina possesses abundant nutraceutical components and holds promise as an anti-inflammatory, hepatoprotective, antioxidant, antimutagenic, cytotoxic, anticancer and apoptotic agent"
PHARMACOLOGICAL PROPERTIES OF SPIRULINA SPECIES: HEPATOPROTECTIVE, ANTIOXIDANT AND ANTICANCER EFFECTS
	2024	FARMACIA, 2023, Vol. 71, 4
"Since the older days, spirulina has been consumed as a vital food supplement derived from algae. The properties of this alga, such as anticancer, antioxidant and hepatoprotective, have great significance in enhancing the quality of life and contributing to better health. The affliction of liver diseases and cancer is widespread among humanity, causing significant health issues. Thus, the importance of the current work is evident. The purpose was to assess the pharmacological properties of spirulina species concerning their capacity to guard the liver, counteract oxidation and combat cancer. In order to find the most comprehensive information, an intensive hunt was launched on various online databases such as Google Scholar, Scopus, PubMed and Medline. The focus was only on complete experimental and clinical works that surfaced between 2000 and 2019. 2064 related articles were found, of which 58 met the requirements of the present work; they were analysed by documentary analysis and grouped into clusters according to their pharmacognosy properties. According to the articles reviewed, spirulina possesses abundant nutraceutical components and holds promise as an anti-inflammatory, hepatoprotective, antioxidant, antimutagenic, cytotoxic, anticancer and apoptotic agent"

م. م. لبنى زهير عبد الكريم (2 بحث)

Lipidomics Application to Explain Acute Cardiotoxicity Induced by Doxorubicin
	2019	Al Mustansiriyah Journal of Pharmaceutical Sciences
"Doxorubicin (DOX) induced cardiotoxicity is one of the important limiting factors for the clinical use of this drug, the exact mechanism underlying the cardiotoxicity is still under debate and different experimental protocols were used. Lipidomics technology was used in this study to investigate the underlying the cardiotoxicity is still under debate and different experimental protocols were used. Lipidomics technology was used in this study to investigate the underlying mechanism of cardiotoxicity induced by DOX. Lipidomics refers to the complete analysis of lipid profile of a cell or organism based on the principles and tools of analytical chemistry particularly mass spectrometry. This study was designed to investigate cardiotoxicity induced by doxorubicin using lipidomics technology. "
Metabolomics Of Metformin's Cardioprotective Effect In Acute Doxorubicin Induced- Cardiotoxicity In Rats
	2021	systematic reviews in pharmacy journal
"ABSTRACT Doxorubicin (DOX) is a powerful anticancer agent with sever cardiotoxic side effect which limits the clinical use. Metformin (MET) is antihyperglycemic drug with potential cardioprotective effect via AMP-activated protein kinase (AMPK) (increases fatty acid oxidation, decreases the production of ROS, maintaining energy homeostasis and apoptosis). Metabolomics technology deals with systematic study of chemical fingerprints of metabolite profiles. Different metabolic processes can be identified which will give information of any change in the metabolic profile of tissues as well as of biofluids after drug administration. This research designed to investigate MET cardioprotective effect against acute cardiotoxicity induced by DOX using metabolomics technology. Methods: Twenty four adult male wistar rats divided into four groups (6 animals each): control group (saline, i.p.); MET group (300mg/kg/day for 7dayes) by gavage; DOX group (20 mg/kg,i.p.) for acute induction of cardiotoxicity; Met + DOX group received DOX (20mg/kg i.p.) and Met (300 mg/kg/day, for 7 days, starting five days prior to DOX treatment) orally with gavage. Assessment of heart tissue metabolomics, serum MDA and GSH in addition to trichrome stain. Results: The results showed that pretreatment with MET (MET+DOX) significantly (p<0.05) reduced the level of acetic acid, cholesterol, palmitic acid, phosphoric acid, pyruvic acid, stearic acid, glucose, myo-inositol, alanine, lysine, and proline. Also, the level of arachidonic acid, hydroxybutyric acid, lactic acid, linoleic acid, oleic acid, oxalic acid, propionic acid, and galactose reduced after pretreatment with MET (MET+DOX). Additionally, (MET +DOX) resulted in significant decrease (p<0.05) in the level of serum MDA as well as significant (p<0.05) increase in serum GSH levels. In addition to significantly decreased collagen fiber production. Conclusion: It can be concluded that MET improved cardiac structure and function, as well as the metabolism of DOX-induced cardiotoxicity group, as it reduced the level of biomarkers associated with cardiotoxicity including (arachidonic, linoleic, oleic, acetic, stearic) acids, cholesterol ,leucine, glucose, mannose, myoinositol as well as hydroxybutyric acid. This indicates that MET induced a metabolic alterations, including the promotion of glycogenolysis, glycolysis, amino acid utilization and antioxidation. Additionally, MET improving energy metabolism and attenuating oxidative stress through suppression of serum MDA and increase the level of GSH as well as decrease fibrosis and structural changes."

م.م الامين احمد كريم عاصي (0 بحث)

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م.م سجى كريم عبد الحسين (2 بحث)

Evaluation of possible renoprotective effect of omega 3,6,9 against cisplatin induce nephrotoxicity in mice
	2023	Medicin and life , مجله واسط للعلوم
Evaluation of possible renoprotective effect of omega 3,6,9 against cisplatin induce nephrotoxicity in mice
	2023	Medicin and life , مجله واسط للعلوم

م.م هدى فارس حسن (1 بحث)

Synthesis, Characterization And Evaluation of Antimicrobial of Some new Azo compounds derived from 2-amino-6-methoxybenzothiazole
	2023	Journal of Cardiovascular Disease Research
This research include the preparation of Schiff bases by the reaction of (2-amino-6- methoxybenzothiazole) with p-aminoacetophenone to product compound [A], and then converted to Azo compounds from the reaction of Schiff base [A] with p-vanillin to product compound [B],and then reacted with different aromatic amines . These compounds character FT-IR ,1HNMR,13C-NMR and Melting points and evaluate their Antimicrobial activity on four types of bacteria , (S. aureus and S. epidermidis) (K. pneumonia and E. coli) .

م.م. مروان ابراهيم عبدالكريم (1 بحث)

Assess the Antiproliferative Impact of Cnicus BenedictusFloral Extract and its Synergy or Antagonistic Effect with Vinblastine on Cervical Cancer Cell Line Proliferation
	2024	IAR Journal of Pharmacy
"Abstract: Adjective: The purpose of this study was to evaluate the inhibitory effect of the extract derived from Cnicus Benedictus blossom on the growth of cervical cancer cells in a laboratory environment. Furthermore, the study intended to explore any possible synergistic impact when mixing the extract with vinblastine. Method: Hela cancer cell line was utilized to determine the cytotoxicity of Cnicus Benedictus L. floral extract, vinblastine and the mixture between them; the concentration involved was raged between (1-10000) µg/ml, for each one, at 24 and 72 incubation periods. Quantitating drug interaction between mixture components was evaluated by utilizing a compusyn computer program for calculation Combination index (CI) and Dose reduction index. Results: The study showcased the efficacy of plant extract in lessening the growth of cervical cancer cells. The inhibition of growth was seen to be dependent on the concentration and time for both the plant extract and the mixture of plant extract and vinblastine. On the other hand, the cytotoxicity behavior of vinblastine was primarily dependent on time. The result of quantitating drug interaction between mixture components showed diverse behavior, at lower concentration exhibiting synergism, mainly at 24 hrs. incubation period. In contrast, moderate and higher concentrations exhibited antagonism. At the same time, the result of the dose reduction index at 24 hrs. of incubation exhibited a favorable reduction in the concentration of vinblastine in the mixture compared with plant extract. In contrast, at 72 hrs. of incubation, all vinblastine and the majority of plant extract concentrations showed an unfavorable reduction. Conclusion: The study showed that the alcoholic extract of Cnicus Benedictus considerably declined the proliferation of cervical cancer cells corresponding to the inhibitory effect of vinblastine. The result also demonstrates that the mixture of vinblastine and plant extract lessens cervical cancer cell proliferation via cycle-specific and non-cycle-specific cytotoxicity. In contrast, vinblastine predominantly has cycle-specific cytotoxicity. Vinblastine and Cnicus Benedictus L. flower extract have two cytotoxic patterns, synergism at lower combination concentrations and antagonism at intermediate and higher doses."

م.م هبة اياد عزيز (1 بحث)

Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets
	2023	Journal of the faculty of Medicine Baghdad
Preparation of telmisartan that not dissolve in media by different method and prepare different polymers

م.د مثنى عطيه صباح (0 بحث)

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د. ازهار عدنان مهدي (0 بحث)

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م.م مكارم دوهان محمود (0 بحث)

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م.د مها حقي اسماعيل (0 بحث)

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م.م صادق جعفر رشيد (8 بحث)

Assess the Antiproliferative Impact of Cnicus BenedictusFloral Extract and its Synergy or Antagonistic Effect with Vinblastine on Cervical Cancer Cell Line Proliferation
	2024	IAR Journal of Pharmacy
"Abstract: Adjective: The purpose of this study was to evaluate the inhibitory effect of the extract derived from Cnicus Benedictus blossom on the growth of cervical cancer cells in a laboratory environment. Furthermore, the study intended to explore any possible synergistic impact when mixing the extract with vinblastine. Method: Hela cancer cell line was utilized to determine the cytotoxicity of Cnicus Benedictus L. floral extract, vinblastine and the mixture between them; the concentration involved was raged between (1-10000) μg/ml, for each one, at 24 and 72 incubation periods. Quantitating drug interaction between mixture components was evaluated by utilizing a compusyn computer program for calculation Combination index (CI) and Dose reduction index. Results: The study showcased the efficacy of plant extract in lessening the growth of cervical cancer cells. The inhibition of growth was seen to be dependent on the concentration and time for both the plant extract and the mixture of plant extract and vinblastine. On the other hand, the cytotoxicity behavior of vinblastine was primarily dependent on time. The result of quantitating drug interaction between mixture components showed diverse behavior, at lower concentration exhibiting synergism, mainly at 24 hrs. incubation period. In contrast, moderate and higher concentrations exhibited antagonism. At the same time, the result of the dose reduction index at 24 hrs. of incubation exhibited a favorable reduction in the concentration of vinblastine in the mixture compared with plant extract. In contrast, at 72 hrs. of incubation, all vinblastine and the majority of plant extract concentrations showed an unfavorable reduction. Conclusion: The study showed that the alcoholic extract of Cnicus Benedictus considerably declined the proliferation of cervical cancer cells corresponding to the inhibitory effect of vinblastine. The result also demonstrates that the mixture of vinblastine and plant extract lessens cervical cancer cell proliferation via cycle-specific and non-cycle-specific cytotoxicity. In contrast, vinblastine predominantly has cycle-specific cytotoxicity. Vinblastine and Cnicus Benedictus L. flower extract have two cytotoxic patterns, synergism at lower combination concentrations and antagonism at intermediate and higher doses."
Physiological Scrutiny about the Hematological effects of Resveratrol as compared with some Statins in Rats
	2024	Scientific Research Journal of Pharmacy
"Abstract: Fifty male rats allocated as five groups were adopted, to elucidate the effect of resveratrol against the statins; lovastatin and rosuvastatin. The results disclosed that cholesterol did cause significant elevations in erythrocyte count, hemoglobin, hematocrit, leukocytes and platelets counts with significant declinations in lymphocytes and monocytes. Rosuvastatin caused significant decrease in hemoglobin, hematocrit and leukocytes and the Lovastatin caused significant declination in the leukocytes only. Resveratrol caused all the parameters to be without significant differences comparing with control group. Further details are disclosed in the results."
Review Article] Nanocarriers for Protein and Peptide Drug Delivery
	2023	Qeios
"Abstract Background: Protein and peptide drugs offer significant promise as therapeutic agents due to their superior efficacy and reduced toxicity compared to conventional chemical drugs. Nevertheless, difficulties with medication delivery techniques impede their practical deployment. Poor absorption limits non-invasive delivery methods such as nasal, pulmonary, and transdermal distribution, whereas oral administration suffers from low bioavailability and stability problems. Parenteral administration involves certain difficulties, such as low patient compliance and pain, but it also shows promise as a protein-based drug delivery method. Aim: This review article aims to explore the development of structure-based nanocarriers designed for drug delivery, which have shown potential to address the limitations associated with protein and peptide drug delivery. Materials and Methods: A complete literature review was undertaken utilizing Google Scholar and other trustworthy scientific sources to acquire relevant material for this study. Keywords included in the search were “Nanocarriers”, “bioavailability”, “absorption”, “peptide”, “protein drug delivery”, and “permeability”. This review investigated peerreviewed publications, research papers, and reviews relating to the issue of inclusion. Results: The review highlights the advancements in structure-based nanocarriers for protein and peptide drug delivery. These nanocarriers have demonstrated reduced side effects and improved therapeutic efficacy compared to free drug molecules. The ability of new and advanced nanocarriers to facilitate targeted drug delivery, overcome physiological barriers, and enable controlled drug release within the body is discussed. Conclusion: By developing structure-based nanocarriers, the problems with conventional drug delivery techniques may be addressed, and protein and peptide medication delivery can be improved. Potential benefits of these nanocarriers include enhanced absorption, tailored drug administration, and greater bioavailability, which might result in safer and more successful treatment results for a range of illnesses"

م.م علي دلو شكر (0 بحث)

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م.م تبارك احمد جاسم (0 بحث)

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م.م. قتيبه ضياء هاشم (0 بحث)

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م.م سماء سلمان ستار (0 بحث)

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م.م محمد بشار القزان (1 بحث)

Thermodynamic and Kinetic Assessment of Cobalt II Adsorption Using Green Synthesized NiO/γ-Al2O3 Nanoparticles
	2025	Salud, Ciencia y Tecnología – Serie de Conferencias
Introduction: Disposal of heavy metals into the water as a result of industrial development might cause a threat Health and the environment. aim of this study was to assess the uptake of Co2+ from aqueous solutions via NiO/ γ-Al2O3 nano catalysts. Methods: The main variables that affect the percentage of metal removal were assessed. It took about 50 minutes to attain equilibrium for the elimination of Co+2 ions. It was discovered that raising the adsorbate concentration and increasing the surface weight somewhat lowered the removal of cobalt ions. Results: The removal of cobalt ions was shown to depend on temperature,due to ecothermic natural of this prosess increasing temperature associated with decrease the elemination . Conclusions: The adsorption seems to be spontaneous, exothermic, and less random according to calculated values of the thermodynamic functions (∆G, ∆H, and ∆S) of the adsorption. After the data were fitted into a number of kinetic models, including the Elovich model, pseudo-first order, pseudo-second order, and intraparticle diffusion equations, it was discovered that the pseudo-second-order model performed the best at describing the adsorption, with a high correlation factor (R2).

م.د سرى صكبان عبد علي (1 بحث)

Impact of cyp2D6 polymorphism on the efficacy of tamoxifen in iraq women with breast cancer
	2023	Journal of Contemporary Medical Sciences ( J. contemp. med. sci.
"Objective :investigate the impact of the CYP2D6 genetic polymorphism on clinical outcome in Iraqi breast cancer patients who were candidates for Tamoxifen therapy. Methods: Comprehensive CYP2D6 genotyping was performed in 140 Iraqi women with breast cancer who were women on adjuvant treatment with tamoxifen. Breast cancer patients recruited into the study were divided into two groups: seventy breast cancer women who had no history of recurrence at the time of sampling and had a long time on tamoxifen without recurrence and seventy breast cancer women who had recurrence at the time of sampling after one year of treatment with tamoxifen therapy. Recurrence free survival (RFS) was determined in the recruited patients. Results: Multiple genetic variants of the gene encoding the CYP2D6 enzyme were detected with significant differences in their frequencies and percentages in both recurrent and non-recurrent groups of breast cancer patients. The findings of this study suggest that interindividual variation in clinical outcome may be related to genetic variation in CYP2D6 enzyme, which is characterized by variable RFS periods. Conclusions: This study revealed that the CYP2D6 enzyme of breast cancer patients who participated in this study is highly polymorphic. The CYP2D6 gene of study participants exhibited different allelic combinations with variable frequencies. The multiple genetic variants (alleles) of the gene encoding the CYP2D6 enzyme exhibited significant differences in their frequencies and percentages in both recurrent and non-recurrent groups of breast cancer patients. .The study revealed variable Recurrence free survival (RFS) with highly polymorphic gene. Our study quotes the presence of increased CYP2D6 enzyme polymorphism is associated with variable clinical response."

م. م. فاتن شاكر حمود (0 بحث)

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م.د. هيثم نجم الدين عبد (0 بحث)

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